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王志勇(长江学者、美国史丹福大学高级研究员)王志勇，1964年10月生，内蒙古人，博士 。植物激素与信号转导创新研究组研究员，博士生导师 。美国斯坦福卡内基科学研究所植物生物学系（Carnegie Institution for Science, Department of Plant Biology）高级研究人员 。
【长江学者、美国史丹福大学高级研究员 王志勇】近年来在植物激素油菜素内酯的生理功能和作用机制研究方面取得了系列突破性进展，研究结果连续发表在Nature、Science等国际顶级杂誌上，在国际植物生物学研究领域产生了积极的影响 。王志勇在美国加州大学洛杉矶分校获得博士学位，之后在着名的索尔克研究所（The Salk Institute and The Howard Hughes Medical Institute）Joanne Chory实验室从事博士后研究工作 。
基本介绍中文名：王志勇
国籍：中国
民族：汉
性别：男
人物简介他的研究工作在植物光周期基因调控机理和油菜素类酯信号转导等领域获得了一些突破性的成果 。首先提出CCA1是一个与Myb-相关的转录因子，结合在光反应基因Lhcb家族保守的启动子元件上，并介导了光敏色素对此类基因家族的诱导表达 。第一个证明CCA1是体内条件下光敏色素调节基因表达中起重要作用的转录因子，和在昼夜节律中的中心作用 。通过生化方法证明BR通过与BRI1胞外域作用启动激酶活性，进而阐明BRI1为油菜素内酯的受体，这是该领域研究的重大进展 。曾在《CELL》、《NATURE》、《SCIENCE》、《PLANT CELL》、《Dev. Cell》和《PNAS》等重要期刊发表多篇学术论文，其中一些被《植物生物化学与分子生物学》引用 。他的研究组进一步克隆到参与油菜素调节基因表达的细胞核内转录因子BZR1，并阐明油菜素通过受体BRI1、胞内激酶BIN2调节BZR1磷酸化和降解的分子机制 。研究方向主要从事 植物激素油菜素内酯（BR）信号转导过程和机理的研究；使用拟南芥、水稻以及棉花为材料，探索BR在植物生长发育调控中的功能和机理 。主要研究集中在以下方面：1. 利用生化和细胞学方法研究BR信号转导中关键转录因子OsBZR1的生理功能；2. 通过生物信息学方法寻找同时参与BR和光信号过程的关键转录因子家族，研究BR与光信号互作的机理 。3. 通过染色体免疫沉澱结合超高通量测序技术大规模分离BR信号重要调控因子BZR1的目的基因和回响元件，并利用激活标籤技术筛选抑制bzr1-1D表型的突变体，研究BR影响植物生长发育过程和生理反应的详细机制 。4. 在水稻T-DNA插入和其它突变体库中寻找叶夹角和株高异常的突变体，克隆基因并研究机理，系统分析BR如何影响株型结构 。5. 通过蛋白组学方法分离BR信号转导途径的新组份 。6. 利用棉花悬浮培养系统和转录组学方法研究BR促进棉花纤维发育的机制 。学习工作经历1992-1998.1: 美国加州大学洛杉矶分校分子、细胞发育生物学获博士学位;1986-1989.6: 中国科学院植物研究所获硕士学位;1982-1986.6: 兰州大学生物学专业获学士学位.部分发表文章1. Tang WQ, Kim TW, Oses-Prieto JA, Sun Y, Deng ZP, Zhu SW, Wang RJ, Burlingame AL, Wang ZY. Brassinosteroid-signaling Kinases(BSKs) mediate signal transduction from the receptor kinase BRI1 in Arabidopsis. Science, 2008，321：557-60. 2. Tang WQ*, Deng ZP*, Oses-Prieto JA*, Suzuki N, Zhu SW, Zhang X, Burlingame AL, and Wang ZY. Proteomic studies of brassinosteroid signal transduction using prefractionation and 2-D DIGE (* These authors contributed equally to this paper). Molecular & Cellular Proteomics, 2008, 7(4): 728-38. 3. Gampala SS, Kim TW, He JX, Tang W, Deng Z, Bai MY, Guan S, Lalonde S, Sun Y, Gendron JM, Chen H, Shibagaki N, Ferl RJ, Ehrhardt D, Chong K, Burlingame AL, Wang ZY. An essential role for 14-3-3 proteins in brassinosteroid signal transduction in Arabidopsis. Dev Cell. 2007 13(2):177-89.4. Bai MY, Zhang LY, Gampala SS, Zhu SW, Song WY, Chong K, Wang ZY. Functions of OsBZR1 and 14-3-3 proteins in brassinosteroid signaling in rice. Proc Natl Acad Sci U S A. 2007 21: 104(34): 13839-44.5. Shi YH, Zhu SW, Mao XJ, Feng JX, Qin YM, Zhang L, Cheng J, Wei LP, Wang ZY and Zhu YX. Transcriptome profiling, molecular biology and physical studies reveal a major role for ethylene in cotton fiber cell elongation. The Plant Cell, 2006. 18: 651-64. 6. Wang ZY, Wang Q, Chong K, Wang F, Wang L, Bai M, Jia C. (2006). The brassinosteroid signal transduction pathway. Cell Res. 16(5):427-34.7. Shi, Y-H., Zhu, S-W., Mao, X-Z., Feng, J-X., Zhang, L., Cheng, J., Wei, L-P., Wang, Z-Y., Zhu, Y-X. (2006) Transcriptome Profiling, Molecular Biological and Physiological Studies Reveal a Major Role for Ethylene in Cotton Fiber Cell Elongation. Plant Cell, 18(3):651-64.8. Jun-Xian He, Joshua M. Gendron, Yu Sun, Srinivas S. L. Gampala, Nathan Gendron, Catherine Qing Sun, and Zhi-Yong Wang (2005). BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses. Science 307, 1634-1638.9. Wang, Zhi-Yong and He, Jun-Xian (2004). Brassinosteroid signal transduction: Choices of signals and receptors. Trends in Plant Science, 9 (2), 91-96.10. He, J-X., Gendron, J. M., Yang, Y. Li, J., Wang, Z-Y. (2002). The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis. Proc. Nat. Acad. Sci, 99, 10185-10990. 11. Green, R.M., Tingay, S., Wang, Z-Y, Tobin, E.M. (2002). Circadian rhythms confer a higher level of fitness to Arabidopsis plants. Plant Physiology 129, 576-584. 12. Yin, Y., Wang, Z-Y, Mora-Garcia, S., Li, J., Yoshida, S., Asami, T., Chory, J. (2002). BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation. Cell 109, 181-191. 13. Wang, Z-Y. et al., (2002). Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis. Dev. Cell, 2, 505-513. 14. Zhi-Yong Wang, Hideharu Setu, Shozo Fujioka, Shigeo Yoshida, and Joanne Chory (2001). BRI1 is a critical component of a plasma membrane receptor for plant steroids. Nature, 410, 380-382. 15. Zuhua He, Zhi-Yong Wang, Jianming Li, Qun Zhu, Chris Lamb, Pamela Ronald, Joanne Chory. (2000) Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1. Science, 288, 2360-3. 16. Detlef Weigel, Ji Hoon Ahn?, Miguel A. Blázquez?, Justin Borevitz?, Sioux K. Christensen?, Christian Fankhauser?, Cristina Ferrándiz?, Igor Kardailsky?, Michael M. Neff?, Jasmine Thuy Nguyen?, Shusei Sato?, Zhi-Yong Wang?, Yiji Xia?, Richard Dixon, Maria J. Harrison, Chris J. Lamb, Martin F. Yanofsky, and Joanne Chory. (2000). Activation tagging in Arabidopsis. Plant Physiology 122, 1003-1013. (? These authors contributed equally to this work). 17. Wang, Z-Y, Tobin, E. M. (1998). Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression. Cell 93, 1207-1217. 18. Sugano, S., Andronis, C., Green, R. M., Wang, Z-Y, and Tobin, E. M. (1998). Protein kinase CK2 interacts with and phosphorylates the Arabidopsis circadian clock-associated 1 protein. Proc. Natl. Acad. Sci. 95, 11020-11025. 19. Wang, Z-Y, Kenigsbuch, D., Sun, L., Harel, E., Ong, M.S., Tobin, E.M. (1997). A Myb-related transcription factor is involved in the phytochrome regulation of an Arabidopsis Lhcb gene. Plant Cell 9, 491-507. 20. Wang, Z-Y, Tang, P-H, (1990). Analysis of S-specific proteins in anther of Brassica pekinensis L. by 2-dimensional electrophoresis. Chinese Journal of Botany (English) 2: 109-115. Review Articles, Book and Symposium Chapters 21.Wang, Z.-Y.* and Chory, J. (2000). Zhi-yong Wang and Joanne Chory. 2000. Recent advances in molecular genetic studies of the functions of brassinolide, A steroid hormone in plants. in Recent Advances in Phytochemistry, Vol. 34. Evolution of Metabolic Pathways, Eds. J.T. Romeo, R. Ibrahim, L. Varin, and V. DeLuca (Elsevier Science. Ltd. Oxford, UK). pp 409-431. (*corresponding author). 22.Tobin, E. M., Degenhardt, J., Harel, E., Kenigsbuch, D., Ong, M. S., Sugano, S., Sun, L., Wang, Z-Y, and Weatherwax, S. C. (1996) Phytochrome-regulated Lhcb promoters. in: Regulation of Plant Growth and Development by Light, Eds. Briggs, R., Heath, R.L., and Tobin, E.M.(American Society of Plant Physiologists, Maryland), pp. 57-66.