基础神经科学系列2：神经系统发育 _生活百科

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基础神经科学系列2：神经系统发育基本介绍书名：基础神经科学系列2:神经系统发育
出版社：科学出版社
页数：532页
开本：16
定价：75.00
作者：Laary Squire Darwin Berg
出版日期：2009年3月1日
语种：英语
ISBN：7030241584, 9787030241580
品牌：科学出版社
基本介绍内容简介生动详实——全书包含530余幅图例和照片，便于读者理解，《神经系统发育(附盘)(导读版·原版引进)》附赠光碟包含全书所有彩图。作者简介作者：(美国)Laary Squire (美国)Darwin Berg (美国)Floyd Bloom Larry R. Squire is Distinguished Professor of Psy-chiatry, Neurosciences, and Psychology at the Univer-sity of California School of Medicine, San Diego, andResearch Career Scientist at the Veterans AffairsMedical Center, San Diego. He investigates the organi-zation and neurological foundations of memory. He isa former President of the Society for Neuroscience andis a member of the National Academy of Sciences andthe Institute of Medicine. Darwin K. Berg is Distinguished Professor in theDivision of Biological Sciences at the University ofCalifornia, San Diego. He has been chairman of theBiology Department and currently serves as Councilorof the Society for Neuroscience and as a Board memberof the Kavli Institute for Brain and Mind. His researchis focused on the roles of nicotinic cholinergic signal-ing in the vertebrate nervous system. Floyd Bloom is Professor Emeritus in the Molecularand Integrative Neuroscience Department （MIND） at The Scripps Research Institute. His recent awardsinclude the Sarnat Award from the Institute of Medi-cine and the Salmon Medal of the New York Academyof Medicine. He is a former President of the Society forNeuroscience and is a member of the NationalAcademy of Sciences and the Institute of Medicine. Sascha du Lac is an Investigator of the HowardHughes Medical Institute and an Associate Professorof Systems Neurobiology at the Salk Institute for Bio-logical Studies. Her research interests are in the neu-robiology of resilience and learning, and her laboratoryinvestigates behavioral, circuit, cellular, and molecularmechanisms in the sense of balance. Anirvan Ghosh is Stephen Kuffler Professor in theDivision of Biological Sciences at the University of California, San Diego and Director of the graduateprogram in Neurosciences. His research interestsinclude the development of synaptic connections inthe central nervous system and the role of activity-dependent gene expression in the cortical develop-ment. He is recipient of the Presidential Early CareerAward for Scientists and Engineers and the Society forNeuroscience Young Investigator Award. Nicholas C. Spitzer is Distinguished Professor inthe Division of Biological Sciences at the University of California, San Diego. His research is focusedon neuronal differentiation and the role of electricalactivity and calcium signaling in the assembly ofthe nervous system. He has been chairman ofthe Biology Department and the Neurobiology Section,a trustee of the Grass Foundation, and served as Councilor of the Society for Neuroscience. He is amember of the American Academy of Arts and Sci-ences and Co-Director of the Kavli Institute for Brainand Mind.图书目录前言作者简介第一部分神经科学总论第1章神经科学基础第2章神经系统概述第二部分细胞和分子神经科学第3章神经组织的细胞元件第4章神经系统的亚细胞结构：细胞器及其功能第5章轴突和树突的电紧张特性第6章跨膜电位和动作电位第7章神经递质第8章神经递质释放第9章神经递质受体第10章细胞内信号第11章突触后电位和突触融合第12章树突内複杂信息处理第13章脑能量代谢第三部分神经系统发育第14章神经诱导和模式形成第15章细胞决定第16章神经发生和迁移第17章生长锥和轴突导向第18章靶体选择、地形图和突触形成第19章细胞程式化死亡及神经营养因子第20章突触消亡第21章树突发育第22章早期经验和敏感期第四部分感觉系统第23章感觉系统基础第24章化学感觉：味觉和嗅觉第25章躯体感觉系统第26章听觉第27章视觉第五部分运动系统第28章运动系统基础第29章脊髓和外周运动系统第30章运动的递减控制第31章基底神经节第32章小脑第33章眼动第六部分调节系统第34章下丘脑：调节系统概述第35章自主功能的控制：自主神经系统的组织第36章心血管系统的神经控制第37章呼吸的神经控制第38章食物摄取及代谢第39章水的摄取及体液第40章神经内分泌系统第41章生理节奏第42章睡眠、做梦和失眠第43章奖励、动机和成瘾第七部分行为和认知神经科学第44章人脑进化第45章认知发育和衰老第46章物体的视觉感知第47章空间识别第48章注意第49章学习与记忆：基础机制第50章学习与记忆：脑系统第51章语言和交流第52章前额叶皮层及脑功能执行第53章意识的神经科学索引文摘插图： Three tyrosine receptor kinases and trk familymembers——trkA, trkB, and trkC——transduce neuro-trophin signals. Signaling pathways used by the trkfamily members are shared with those activated bymany other growth factor receptors. Neurotrophinbinding to trk causes receptor dimerization and phos-phorylation of cytoplasmic tyrosine residues. Phos-photyrosines recruit cytosolic adaptor proteins thatcouple the activated receptor with intracellular signal-ing pathways. The biological response of the cell to aneurotrophic factor is dependent on the dynamicstatus of the pathway that can vary with recent cellhistory. Three of the best investigated signaling path-ways are PLC-y, Ras-ERK kinase, and PI-3K. NormalPCD is governed in many neurons by PI-3 kinaseactivation of the protein kinase Akt. Trophic factordeprivation can lead to the release of pro-apoptoticmechanisms that promote cell death. 序言人脑或神经系统是我们已知的宇宙中最複杂的物质结构，神经科学是探索脑的奥秘的科学，是21世纪迅猛发展的生命科学中最为突出的领域之一。过去的十多年中，分子生物学和计算机科学技术的快速发展，极大地推动了神经科学的发展，人类基因组DNA序列的阐明及其对神经科学的推动、脑功能成像技术研究人脑和心理活动的巨大进展便是最突出的代表。对许多神经元活动的基本过程，神经科学家已经可以通过基因操作，在基因及其编码的蛋白分子的结构和功能水平上进行描述和分析，从而精细地研究其複杂的细胞膜上和胞内信号的调控分子机制。脑功能成像技术使得过去只能停留在人脑这个“黑箱”外、对心理现象的脑机制进行各种猜测和假说的时代成为过去，人脑的认知和思维活动变得“看得见”了。神经科学不仅吸引着各类神经生物学家、化学家和物理学家，而且吸引分子生物学家、计算机科学家和心理学家纷纷加入其中，成为真正意义上的多种学科交叉的科学。