黄志纾( 二 )

    周翔,曲小刚,张亮仁,黄志纾,马文宾,翁小成,赵传奇,第19章:基于化学小分子探针的染色体端粒DNA结构、功能和信号转导研究,《化学生物学学科前沿与展望》(中国化学科学丛书),蒋华良,陈拥军,陈鹏,张礼和主编,科学出版社,2013年8月出版,pp485-520.
    Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, Lian-Quan Gu, Chapter 5: G-quadruplex DNA and its ligands in anticancer therapy,《Medicinal Chemistry of Nucleic Acids》,Edited by Li-He Zhang, Zhen Xi, and Jyoti Chattopadhyaya, John Wiley & Sons, Inc., published in August 2011, pp206-257 。
    黄志纾,卢宇靖,谭嘉恆,古练权,以G-四链体DNA为靶点的药物分子设计研究进展.《药物化学进展》系列丛书第六卷,彭司勛主编,化学工业出版社,2009年8月出版,pp100-117 。
    古练权,黄志纾,人类基因G-四链体结构的化学基因组学研究的基本问题,《10000个科学难题》(化学卷),科学出版社,2009年5月,pp637 。
    Z.-S. Huang, X. Zhou and Z. Tan, Thematic Issue: Biological Function of G-Quadruplex Nucleic Acids and Potential Application in Medicinal Chemistry,Current Topics in Medicinal Chemistry2015, 15(19), Pp. 1939-2001. (SCI IF 3.402,专刊客座主编)
部分代表性论文(均为通讯作者):
    Discovery of novel schizocommunin derivatives as telomeric G-quadruplex ligands that trigger telomere dysfunction and the deoxyribonucleic acid (DNA) damage response,J. Med. Chem.2018,61, 3436–3453.
    Design, synthesis, and evaluation of new selective NM23-H2 binders asc-MYCtranscription inhibitors via disruption ofthe NM23-H2/G-quadruplex interaction,J. Med. Chem.2017,60, 6924–6941.
    New disubstituted quindoline derivatives inhibiting Burkitt’s lymphoma cell proliferation by impeding c-MYC transcription,J. Med. Chem.2017,60, 5438–5454.
    Natural alkaloid bouchardatine ameliorates metabolic disorders in high‐fat diet‐fed mice by stimulating the sirtuin 1/liver kinase B‐1/AMPK axis,Brit. J. Pharmacol.2017,174, 2457-2470.
    Design, synthesis and evaluation of isaindigotone derivatives to downregulatec-myctranscription via disrupting the interaction of NM23-H2 with G-quadruplex,J. Med. Chem.2017,60, 1292-1308.
    Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole,Nucleic Acids Res.2017,45, 1606-1618.
    Conformation selective antibody enables genome profiling and leads to discovery of parallel G-quadruplex in human telomeres.Cell Chem. Biol.2016,23, 1261-1270.
    Visualization ofNRASRNA G-quadruplex structures in cells with an engineered fluorogenic hybridization probe.J. Am. Chem. Soc.2016,138, 10382–10385.
    Synthesis and mechanism studies of 1,3-benzoazolyl substituted pyrrolo[2,3b]pyrazine derivatives as nonintercalative topoisomerase II catalytic inhibitors,J. Med. Chem.2016, 59, 238-252.
    Synthesis and biological evaluation of novel bouchardatine derivatives as potential adipogenesis/lipogenesis inhibitors for antiobesity treatment,J. Med. Chem.2015,58, 9395-9413.
    A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region,Oncotarget2015,6, 35625-35635.
    Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule,Nucleic Acids Res.2015,43, 6677-6691.
    Discovery of small molecules for up-regulating the translation of antiamyloidogenic secretase, a disintegrin and metalloproteinase 10 (ADAM10), by binding to the G-quadruplex-forming sequence in the 5′ untranslated region (UTR) of Its mRNA,J. Med. Chem.2015,58, 3875-91.
    Identification of selective G-quadruplex DNA binder by a multistep virtual screening approach,