Environ Mol Mutagen. 2019 Jan;60(1):56-71. doi: 10.1002/em.22227. Epub 2018 Sep 21.
Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo.Fu Y, Hong L, Xu J, Zhong G, Gu Q, Gu Q, Guan Y, Zheng X, Dai Q, Luo X, Liu C,Huang Zhiying, Yin XM, Liu P*, Li M*.Autophagy. 2018 Sep 3. doi: 0.1080/15548627.2018.1517073. [Epub ahead of print]
Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes.Xi Y, Wang W, Wang L, Pan J, Cheng Y, Shen F*,Zhiying Huang*.Toxicol Appl Pharmacol.2018 Sep 15;355:269-285. doi: 10.1016/j.taap.2018.07.011. Epub 2018 Jul 20.
Triptolide-induced mitochondrial damage dysregulates fatty acid metabolism in mouse sertoli cells.Cheng Y, Chen G, Wang L, Kong J, Pan J, Xi Y, Shen F*,Zhiying Huang* Toxicol Lett.2018 Aug;292:136-150. doi: 10.1016/j.toxlet.2018.04.035. Epub 2018 Apr 30.
Triptolide induces mitochondria-mediated apoptosis of Burkitt's lymphoma cell via deacetylation of GSK-3β by increased SIRT3 expression.Kong J, Wang L, Ren L, Yan Y, Cheng Y,Zhiying Huang*, Shen F*.Toxicol Appl Pharmacol. 2018 Mar 1;342:1-13. doi: 10.1016/j.taap.2018.01.011. Epub 2018 Feb 4.
Inhibition of glycogen synthase kinase 3beta ameliorates triptolide-induced acute cardiac injury by desensitizing mitochondrial permeability transition.Wang W, Yang Y, Xiong Z, Kong J, Fu X, Shen F*,Zhiying Huang*Toxicol Appl Pharmacol. 2016 Oct 14. pii: S0041-008X(16)30308-8. doi: 10.1016/j.taap.2016.10.007.
Immunotoxicological Evaluation of Genetically Modified Rice Expressing Cry1Ab/Ac Protein (TT51-1) by a 6-Month Feeding Study on Cynomolgus Monkeys.Tan X, Zhou X, Tang Y, Lv J, Zhang L, Sun L, Yang Y, Miao Y, Jiang H, Chen G,Zhiying Huang*, Wang X*.PLoS One. 2016 Sep 29;11(9):e0163879. doi: 0.1371/journal.pone.0163879. eCollection 201
A high-throughput Bhas 42 cell transformation assay for the determination of the carcinogenicity of three herbal extracts 。Jiang Pu, Ying Wang, Naisong Qi, Wenwan Du, Xiaoyan Tan, Gaofeng Chen, Hairuo Wen, Xin Wang, Yanping Hu, Jie Song, Yuwen Qiu, Jinqiang Liang, Xinlu Fu,Zhiying Huang* , Xue Wang*Fundam. Toxicol. Sci.Vol.3, No.4, 157-166, 2016
Resveratrol protects against triptolide-induced cardiotoxicity through SIRT3 signaling pathwayin vivoandin vitro.Yang Y, Wang W, Xiong Z, Kong J, Wang L, Qiu Y, Shen F,Zhiying Huang*Pharmazie. 2016 Sep 1;71(9):514-523. doi: 10.1691/ph.2016.6597
Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway.Wang W, Guan C, Sun X, Zhao Z, Li J, Fu X, Qiu Y, Huang M, Jin J,Zhiying Huang* Phytomedicine. 2016 Jun 1;23(6):589-96. doi: 10.1016/j.phymed.2016.02.022. Epub 2016 Mar 22.
Activation of SIRT3 attenuates triptolide-induced toxicity through closing mitochondrial permeability transition pore in cardiomyocytes.Yang Y, Wang W, Xiong Z, Kong J, Qiu Y, Shen F,Zhiying Huang* Toxicol In Vitro. 2016 Aug;34:128-37. doi: 10.1016/j.tiv.2016.03.020. Epub 2016 Apr 8.
Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.Jin J, Sun X, Zhao Z, Wang W, Qiu Y, Fu X, Huang M,Zhiying Huang*. Phytomedicine. 2015 Sep 15;22(10):894-901. doi: 10.1016/j.phymed.2015.06.007. Epub 2015 Jul 3.
Autophagy plays an important role in triptolide-induced apoptosis in cardiomyocytes.Zhou J, Xi C, Wang W, Yang Y, Qiu Y,Zhiying Huang* Toxicol Lett.2015 Aug 5;236(3):168-83. doi: 10.1016/j.toxlet.2015.05.013. Epub 2015 May 22
Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response.Jin J, Li M, Zhao Z, Sun X, Li J, Wang W, Huang M,Zhiying Huang*，Phytomedicine. 2015 May 15;22(5):528-35. doi: 10.1016/j.phymed.2015.03.003. Epub 2015 Mar 20
Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice.Jin J, Xiong T, Hou X, Sun X, Liao J,Zhiying Huang, Huang M, Zhao Z.