黎明涛 _生活百科

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黎明涛【黎明涛】黎明涛,中山大学中山医学院药理教研室教授，博士生导师，中山大学蛋白质组学研究中心教授、主任。1984年、1989年和1996年分别获得医学学士、硕士和博士学位。学科专业为药理学与分子神经生物学，主要研究领域是神经元凋亡的信号转导与基因调控、帕金森病、蛋白质组学。在美国Department of Pharmacology, University of Colorado Health Sciences Center（1999-2001）从事神经元凋亡的信号转导与基因调控、帕金森病机理与新靶点和蛋白质组学研究。
基本介绍中文名：黎明涛
职业：教授
研究项目：分子神经生物学
性别：男
研究方向神经元凋亡的信号转导、基因调控；帕金森病；蛋白质组学研究成果2001年回国，获得“211”基金200万元，组建了一流的分子、细胞生物学实验室。自2002年以来，作为负责人获得一期“985”学科建设经费700万元，筹建了一流的蛋白质组学实验室并正在开展蛋白质科学的前沿性工作。近年来，培养和汇聚了一支从事蛋白质组学、细胞和分子生物学研究的高素质科研队伍。近年来，黎明涛作为第一主持人获得18项基金，包括5项国家自然科学基金，5项广东省自然科学基金，4项广州市科技局项目以及教育部、卫生部的重点项目基金近500万元。在各项基金的支持下，课题组共发表了SCI论文20篇，其中黎明涛作为第一作者在国际核心杂誌Molecular and Cellular Biology(IF, 10.03)和 Journal of Neuroscience(IF, 8.4)发表了具有创新性的文章；作为通讯作者，在Neuroscience Research(IF, 2.4) 和Neuroscience Letters （IF，2.2）上发表了3篇开拓性文章，并在 Drug News Perspect（IF，0.524）上发表了相关专题综述。研究项目1、分子神经生物学海外或港、澳杰出青年学者合作研究基金 2007.1-2009.12 项目批准号：30629002 40万2、c-Jun靶基因及其对神经元凋亡的调控联合资助基金项目/重点项目2007.1-2010.12 项目编号：U0632006 140万3、神经元凋亡时SP1对BH3-only蛋白Bim的转录调控国家自然科学基金2006.1-2008.12 项目编号：30570562 35万4、靛玉红衍生物治疗帕金森病的研究与开发广东省科技计画项目——国际科技合作计画 2007.1-2009.12 项目编号2006B50103001 10万5、转录因子MEF2对神经元凋亡调控作用及其信号转导国家自然科学基金2004.1-2006.12 项目编号：30370450 25万论文发表1. Mingtao Li，Xiaomin Wang，Mary Kay Meintzer，Tracey Laessig，Morris J. Birnbaum and Kim A. Heidenreich. Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3β. Mol Cell Biol. 2000, 20（24）：9356-9363.2. Mingtao Li，Daniel A. Linsenman，Melissa P.Allen，Mary Kay Meintzer，Xiaomin Wang，Tracey Laessig，Margaret E. Wierman & Kim A. Heidenreich. MEF2A and MEF2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. J. Neurosci. 2001, 21(17):6544-6552.3. Leyu Shi , Shoufang Gong, Zhongmin Yuan , Chi Ma, Yanling Liu, Chuanfu Wang , Wenming Li, Rongbiao Pi, Shoujian Huang, Ruzhu Chen , Yifan Han , Zixu Mao, and Mingtao Li(通讯作者). Activity deprivation-dependent induction of the proapoptotic BH3-only protein Bim is independent of JNK/c-Jun activation during apoptosis in cerebellar granule neurons. Neurosci Lett. 2005, 375:7-12.4. Wenya Wang, Chi Ma, Zixu Mao and Mingtao Li. (通讯作者). JNK inhibition as a potential strategy in treating Parkinsons’s disease. Drug News Perspect. 2004, 17(10):646-654.5. Wenya Wang, Leyu Shi, Yuanbin Xie, Chi Ma, Wenming Li, Xingwen Su, Shoujian Huang, Ruzhu Chen, Zhenyu Zhu, Zixu Mao, Yifan Han and Mingtao Li. (通讯作者). SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson’s disease. Neurosci Res 2004,48:195-202.6. Yuanbin Xie, Yanling Liu, Chi Ma, Zhongmin Yuan, Wenya Wang, Zhenyu Zhu, , Guoquan Gao, Xianguo Liu, Hengxin Yuan, Ruzhu Chen, Shoujian Huang, Xuelan Wang, Xiaonan Zhu, Xuemin Wang, Zixu Mao and Mingtao Li (通讯作者). Indirubin-3′-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons. Neurosci Lett. 2004, 367:355-359. 7. Rongbiao Pi, Wenming Li Nelson T.K.Lee, Hugh H.N.Chan, Yongmei Pu, Ling Nga Chan, Nikolaus J.Sucher, Doanld C. Chang, Mingtao Li and Yifan Han. Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways. J Neurochem. 2004, 91:1212-1230.8. Wenming Li, Rongbiao Pi, Hugh H. N. Chan, Hongjun Fu, Nelson T. K. Lee, Hing Wai Tsang, Yongmei Pu, Donald C. Chang, Chaoying Li, Jialie Luo, Keming Xiong, Zhiwang Li, Hong Xue, Paul R. Carlier, Yuanping Pang, Karl W. K. Tsim, Mingtao Li and Yifan Han. Novel dimeric AChE inhibitor Bis(7)-tacrine, but not Donepezil, prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. J Biol Chem. 2005, 280(18):18179-18188.9. Xuemin Wang, Xiaoli Tang, Mingtao Li, John Marshall, Zixu Mao. Regulation of neuroprotective activity of myocyte enhancer factor 2 by cAMP-PKA signaling pathway in neuronal survival. J Biol Chem. 2005, 280(17):16705-167013.10. Daniel A. Linseman, Christopher M. Bartley, Shoshona S. Le, Tracey A. Laessig, Ron J. Bouchard, Mary Kay Meintzer, Mingtao Li and Kim A. Heidenreich . Inactivation of the Myocyte Enhancer Factor-2 Repressor Histone Deacetylase-5 by Endogenous Ca2/Calmodulin-dependent Kinase II Promotes Depolarization-mediated Cerebellar Granule Neuron Survival. J Biol Chem 2003, 278:41472–41481.11. Jing-Ping Yun, Choong-Tsek Liew, Eng Ching Chew, Xiao-Yu Yin, Paul Bo San Lai, Yam Hin Fai, H.K. Richard Li, Mei-Lin Jin, Ming-Xiao Ding, Mingtao Li, Han-Liang Lin, and Wan Yee Lau. Nuclear Matrix Protein Expressions in Hepatocytes of Normal and Cirrhotic Rat Livers Under Normal and Regenerating Conditions. J Cell Biochem. 2004, 91:1269–1279. 12. Hongwei Yang, Xiaodong Hu, Hongmei Zhang, Wenjun Xin, Mingtao Li, Tong Zhang, Lijun Zhou and Xianguo Liu. Roles of CaMKII, PKA, and PKC in the induction and mainternance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn. J Neurophysiol. 2004, 91: 1122-1133.13. Nengwei Hu, Hongmei Zhang, Xiaodong Hu , Mingtao Li, Tong Zhang, Lijun Zhou and Xianguo Liu. Protein Synthesis Inhibition Blocks the Late-Phase LTP of C-Fiber Evoked Field Potentials in Rat Spinal Dorsal Horn. J Neurophysiol. 2003,89: 2354- 2359.14. Juan Sun, Mingtao Li, Jiahuai Han and Jun Gu. Sensitization of differentiated PC12 cells to apoptosis by presenilin-2 is mediated by p38. Biochem. Biophy. Res. Commun. 2001, 287: 536-541.15. Marcus Wiedmann, Xuemin Wang, Xiaoli Tang, Mingtao Li, Zixu Mao. PI3K/Akt-dependent regulation of the transcription factor myocyte enhancer factor-2 in insulin-like growth factor-1- and membrane depolarization-mediated survival of cerebellar granule neurons. J Neurosci Res. 2005, 81(2):226-234.16. Weibin Cai, Jianfang Ma , Chaoyang Li, Zhonghan Yang, Xia Yang, Wei Liu , Zuguo Liu , Mingtao Li, Guoquan Gao. Enhanced anti-angiogenic effect of a deletion mutant of plasminogen kringle 5 on neovascularization. J Cell Biochem. 2005,96(6):1254-1261.17. Ming Yang, Wei Liu, Chunyou Wang, Tao Liu, Feng Zhou, Jing Tao, Yang Wang, Mingtao Li. Proteomic Analysis in the Early Process of Pancreatic Regeneration in the Pancreatectomized Rat. Acta Pharmacol Sin. 2006, 27(5):568-578. 18. Hongjun Fu, Wenming Li, Yuanzhi Lao, Jialie Luo, Nelson T. K. Lee, Kelvin K. W. Kan, Hing Wai Tsang, Karl W. K. Tsim, Yuanping Pang, Zhiwang Li, Donald C. Chang, Mingtao Li and Yifan Han. Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels. J Neurochem. 2006 Jun 12; [Epub ahead of print]19. Wenming Li, Nelson T.K. Lee, Hongjun Fu, Kelvin K.W. Kan, Yuanping Pang, Mingtao Li, Tsim, W.K. Karl, Xiaoyuan Li, Yifan Han. Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine. Neuroreport. 2006,17(5):471-474.20. Rong Deng, Wenming Li, Zhong Guan, Junmin Zhou, Yi Wang, Yuping Mei, Mingtao Li, Gongkan Feng, Wenlin Huang, Zongchao Liu, Yifan Han, Yixin Zeng and Xaofeng Zhu. Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. Oncogene. 2006 May 22; [Epub ahead of print]