中山大学中山医学院神经科学研究中心独立PI 蒋斌( 二 ) _生活百科

Eur. J. Neurosci. 2001；Jiang et al. J. Neurosci. 2003; Jiang et al. Eur. J. Neurosci. 2004）。6）创立了一种在体的, 在脑的指定部位通过电极电穿孔方法导入干扰RNA（siRNA）使局部组织细胞里的指定基因被封闭而降低表达，从而研究这些基因功能的方法[Yukio Akaneya, Bin Jiang, Tadaharu Tsumoto (2005) RNAi-induced gene silencing by local electroporation in targeting brain region. J. Neurophysiology, 93: 594-602] 。该方法自从 2005 年发表后，已被同行引用了70多次。发表当年即被 Faculty 1000 Biology 美国神经科学家 John Hildebrand 推荐为“必读的新方法” 。学术论着与教材：1. Bin Jiang*, Kazuhiro Sohya, Abdolrahman Sarihi, Yuchio Yanagawa, Tadaharu Tsumoto* (2010) Laminar-specific maturation of GABAergic transmission and susceptibility to visual deprivation are related to endocannabinoid sensitivity in mouse visual cortex. Journal of Neuroscience 30: 14261-14272. (Equally corresponding authors)2. Bin Jiang, Shiyong Huang, Roberto de Pasquale, Daniel Millman, Lihua Song, Hey-Kyoung Lee, Tadaharu Tsumoto, Alfredo Kirkwood (2010) The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period. Neuron 66: 248-259.3. Toshimitsu Suzuki, Hiroyuki Miyamoto, Takashi Nakahari, Ikuyo Inoue, Takahiro Suemoto, Bin Jiang, Yuki Hirota, Shigeyoshi Itohara, Takaomi C. Saido, Tadaharu Tsumoto, Kazunobu Sawamoto, Takao K. Hensch， Antonio V. Delgado-Escueta, Kazuhiro Yamakawa (2009) Efhc1/myoclonin1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. Human Molecular Genetics 18: 1099-1109. 4. Abdolrahman Sarihi, Bin Jiang, Alireza Komaki, Kazuhiro Sohya, Yuchio Yanagawa, Tadaharu Tsumoto (2008) Metabotropic glutamate receptor type 5-dependent long-term potentiation of excitatory synapses on fast-spiking GABAergic neurons in mouse visual cortex. Journal of Neuroscience28: 1224-1235.5.Bin Jiang, Mario Trevi?o, Alfredo Kirkwood (2007) Sequential development of long-term potentiation and depression in different layers of the mouse visual cortex. Journal of Neuroscience 27: 9648-9652.6. Anubhuthi Geol*, Bin Jiang*, Linda W. Xu, Lihua Song, Alfredo Kirwood, Hey-Kyoung Lee (2006) Cross-modal regulation of synaptic AMPA receptors in primary sensory cortices by visual experience. Nature Neuroscience 9: 1001-1003. (Equally contributing authors)7. Se-Young Choi, Jeff Chang, Bin Jiang, Geun-Hee Seol, Sun-Seek Min, Jung-Soo Han, Hee-Sup Shin, Michela Gallagher, Alfredo Kirkwood (2005) Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex. Journal of Neuroscience 25: 11433-11443.8. Bin Jiang, Z. Josh Huang, Bernardo Morales, Alfredo Kirkwood (2005) Maturation of GABAergic transmission and the timing of plasticity in visual cortex. Brain Research Reviews 50: 126-133.9. Yukio Akaneya, Bin Jiang, Tadaharu Tsumoto (2005) RNAi-induced gene silencing by local electroporation in targeting brain region. Journal of Neurophysiology 93: 594-602. 10. Bin Jiang, Akihiko Kitamura, Hiroki Yasuda, Kazuhiro Sohya, Atsushi Maruyama, Yuchio Yanagawa, Kunihiko Obata, Tadaharu Tsumoto (2004) Brain-derived neurotrophic factor acutely depresses excitatory synaptic transmission to GABAergic neurons in visual cortical slices. European Journal of Neuroscience 20: 709-718.11.Bin Jiang, Yukoi Akaneya, Yoshio Hata, Tadaharu Tsumoto (2003) Long-term depression is not induced by low frequency stimulation in visual cortex in vivo: Possible preventing role of endogenous brain-derived neurotrophic factor. Journal of Neuroscience 23: 3761-3770.12. Bin Jiang, Yukoi Akaneya, Minoru Ohshima, Satoshi Ichisaka, Yoshio Hata, Tadaharu Tsumoto (2001) Brain-derived neurotrophic factor induces long-lasting potentiation of synaptic transmission in visual cortex in vivo in young rats, but does not in the adult.