J. Med. Chem. 2017, DOI: 10.1021/acs.jmedchem.7b00523.[2] Huang, Y.; Liu, X.; Wu, D.; Tang, G.; Lai, Z.; Zheng, X. *; Yin. S. *; Luo, H.-B. * The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata. Biochem. Pharmacol. 2017, 130, 51-59.[3] Zhang, C.; Feng, L.J.; Huang, Y.; Wu, D.; Li, Z.; Zhou, Q.; Wu, Y. *; Luo, H.-B.* Discovery of Novel Phosphodiesterase-2A Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay. J. Chem. Inf. Model. 2017, 57, 355-364.[4] Cai, Y. H.; Guo, Y.; Li, Z.; Wu, D.; Li, X.; Zhang, H.; Yang, J.; Lu, H.; Sun, Z.; Luo, H.-B.; Yin, S.*; Wu, Y*. Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4. Eur. J. Med. Chem. 2016, 114, 134-140.[5] Wu, Y.;* Cheng, J.; Wu, D.; Gu, Q.; Luo, Z.Y.; Luo, H.-B.* Palladium-catalyzed C–H bond carboxylation of acetanilides: an efficient usage of N,N-dimethyloxamic acid as the carboxylate source. Chem. Commun. 2016, 52, 1286-1289. PMID: 26616015 [6] Su, T.; Zhang, T.; Xie, S.; Yan, J.; Wu, Y.; Li, X.; Huang, L.*; Luo, H.-B. *. Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer's disease. Sci. Rep. 2016, 6:21826. PMID: 26911795[7] Wu, Y.*; Sun, L.; Chen, Y.; Zhou, Q.; Huang, J.W.; Miao, H.; Luo, H.-B.* Palladium-Catalyzed Decarboxylative Acylation of N-Nitrosoanilines with α-Oxocarboxylic Acids. J. Org. Chem. 2016, 81(3):1244-1250. PMID: 26746881[8] Li, Z.; Wu, Y., Feng, L.J.; Wu, R.*; Luo, H.-B.* Ab Initio QM/MM Study Shows a Highly Dissociated SN2 Hydrolysis mechanism for the cGMP-specific phosphodiesterase-5. J. Chem. Theory Comput. 2015, 10, 5448-5457.[9] Huang, M.; Shao, Y.; Hou, J.; Cui, W.; Liang, B.; Huang, Y.; Li, Z.; Wu, Y.; Zhu, X.; Liu, P.; Wan, Y.*; Ke. H.*; Luo, H.-B.* Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol. Pharmacol. 2015, 88(5):836-845. PMID: 26316540[10] Zhou, J.; Wu, R.*;Luo, H.-B.* Inhibition mechanism of SAHA in HDAC: a revisit. Phys. Chem. Chem. Phys. 2015, 17(44):29483-29488. PMID: 26497064[11] Li, Z.; Lu, X.; Feng, L.J.; Gu, Y.; Li, X.; Wu, Y.;* Luo, H.-B.* Molecular dynamics-based discovery of novel phosphodiesterase-9A inhibitors with non-pyrazolopyrimidinone scaffolds. Mol. Biosyst. 2015, 15, 115-125. PMID: 25328054. [12] Shao, Y.X.; Huang, M.; Cui, W.; Feng, L.J.; Wu, Y.; Cai, Y.; Li, Z.; Zhu, X.; Liu, P.; Wan, Y.;* Ke, H.*; Luo, H.-B.* Discovery of a phosphodiesterase-9A inhibitor as a potential hypoglycemic agent. J. Med. Chem. 2014, 57, 10304-130313. PMID: 25432025.[13] Shang, N.N.; Shao, Y.X.; Cai, Y.H.; Guan, M.; Huang, M.; Cui, W.; He, L.; Yu, Y.J.; Huang, L.; Li, Z.; Bu, X. Z.*; Ke, H.*; Luo, H.-B.* Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure. Biochem. Pharmacol.2014, 89: 86-98. PMID:24565909[14] Wu, Y.; Feng, L.J.; Lu, X.; Kwong, F.Y.*; Luo, H.-B.* Palladium-catalyzed oxidative C-H bond acylation of N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize N-alkyl-2-aminobenzophenones. Chem. Commun. 2014, 50(97), 15352-15354. PMID: 25348462[15] Zhou, J., Xie, H.; Liu, Z.;Luo, H.-B.*; Wu, R.* Structure-Function Analysis of the Conserved Tyrosine and Diverse π-Stacking among Class I Histone Deacetylases: A QM (DFT)/MM MD Study. J. Chem. Inf. Model. 2014, 54(11), 3162-3171. PMID: 25360823[16] Liu, X.(#); Luo, H.-B.(#,并列第一作者); Huang, Y.Y.; Bao, J.M.; Tang, G.H.; Chen, Y.Y.; Wang, J.; Yin, S. Selaginpulvilins A-D, New phosphodiesterase-4 inhibitors with an unprecedented skeleton from Selaginella Pulvinata. Org. Lett. 2014, 162, 282-285. PMID: 24328835.[17] Cheng, Z.B.; Lu, X.; Bao, J. M.; Han, Q.; Tang, G.H.; Gan, L.S.;Luo, H.-B.*; Yin, S.* (±)-Torreyunlignans A.D, Rare 8-9’ Linked Neolignan Enantiomers as Phosphodiesterase-9A Inhibitors from Torreya yunnanensis